Novel N ‐Cycloalkylcarbonyl‐ N ′‐arylthioureas: Synthesis, Design, Antifungal Activity and Gene Toxicity

A synthesis method of novel N ‐cycloalkylcarbonyl‐ N ′‐arylthioureas was developed. It consists of sequential addition of equimolecular amounts of ammonium isothiocyanate and substituted anilines to cycloalkylcarbonyl chlorides. The identity and purity of products were confirmed by LC/MS spectra, their structure by elemental analysis, IR and 1 H‐NMR spectra. Preliminary antimicrobial screening for standard microorganisms and molecular docking...