Identification of Human Single-Domain Antibodies against SARS-CoV-2
Abstract
The worldwide spread of COVID-19 highlights the need for an efficient approach to rapidly develop therapeutics and prophylactics against SARS-CoV-2. The SARS-CoV-2 spike protein, containing the receptor-binding domain (RBD) and S1 subunit involved in receptor engagement, is a potential therapeutic target. We describe the development of a phage-displayed single-domain antibody library by grafting naive complementarity-determining regions (CDRs)...
Paper Details
Title
Identification of Human Single-Domain Antibodies against SARS-CoV-2
Published Date
Jun 1, 2020
Journal
Volume
27
Issue
6
Pages
891 - 898.e5
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Notes
History