High‐throughput profiling reveals perturbation of endoplasmic reticulum stress‐related genes in atherosclerosis induced by high‐cholesterol diet and the protective role of vitamin E

Formation of atherosclerotic plaques, called atherogenesis, is a complex process affected by genetic and environmental factors. It was proposed that endoplasmic reticulum (ER) stress is an important factor in the pathogenesis of atherosclerosis and that vitamin E affects atherosclerotic plaque formation via its antioxidant properties. Here, we investigated ER stress‐related molecular mechanisms in high‐cholesterol diet (HCD, 2%)‐induced...