Original paper
Napabucasin (BBI 608), a potent chemoradiosensitizer in rectal cancer
Abstract
Background The induction of reactive oxygen species (ROS) represents a viable strategy for enhancing the activity of radiotherapy. The authors hypothesized that napabucasin would increase ROS via its ability to inhibit NAD(P)H:quinone oxidoreductase 1 and potentiate the response to chemoradiotherapy in rectal cancer via distinct mechanisms. Method Proliferation studies, colony formation assays, and ROS levels were measured in HCT116 and HT29...
Paper Details
Title
Napabucasin (BBI 608), a potent chemoradiosensitizer in rectal cancer
Published Date
May 8, 2020
Journal
Volume
126
Issue
14
Pages
3360 - 3371
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Notes
History