Original paper
BCR selection and affinity maturation in Peyer’s patch germinal centres
Abstract
The antigen-binding variable regions of the B cell receptor (BCR) and of antibodies are encoded by exons that are assembled in developing B cells by V(D)J recombination1. The BCR repertoires of primary B cells are vast owing to mechanisms that create diversity at the junctions of V(D)J gene segments that contribute to complementarity-determining region 3 (CDR3), the region that binds antigen1. Primary B cells undergo antigen-driven BCR affinity...
Paper Details
Title
BCR selection and affinity maturation in Peyer’s patch germinal centres
Published Date
May 6, 2020
Journal
Volume
582
Issue
7812
Pages
421 - 425
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Notes
History