Efficient Nonviral Stable Transgenesis Mediated by Retroviral Integrase.

Volume: 17, Pages: 1061 - 1070
Published: May 3, 2020
Abstract
Efficient transgene delivery is critical for genetic manipulation and therapeutic intervention of target cells. Two well-characterized integrative systems have been described that rely on viral and nonviral vectors. However, use of viral vectors for gene therapy has been associated with several safety concerns. Here, we report a virus-free method for stable transgenesis based on the reaction of retroviral integrase. We constructed a gateway...
Paper Details
Title
Efficient Nonviral Stable Transgenesis Mediated by Retroviral Integrase.
Published Date
May 3, 2020
Volume
17
Pages
1061 - 1070
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