From mini-puberty to pre-puberty: early impairment of the hypothalamus–pituitary–gonadal axis with normal testicular function in children with non-mosaic Klinefelter syndrome

Volume: 44, Issue: 1, Pages: 127 - 138
Published: May 6, 2020
Abstract
Klinefelter syndrome (KS) is a genetic disorder caused by the presence of an extra X chromosome in males. The aim of this study was to evaluate the hypothalamic–pituitary–gonadal (HPG) axis and the clinical profile of KS boys from mini-puberty to early childhood. In this retrospective, cross-sectional, population study, 145 KS boys and 97 controls aged 0–11.9 years were recruited. Serum FSH, LH, testosterone (T), Inhibin B (INHB), sex hormone...
Paper Details
Title
From mini-puberty to pre-puberty: early impairment of the hypothalamus–pituitary–gonadal axis with normal testicular function in children with non-mosaic Klinefelter syndrome
Published Date
May 6, 2020
Volume
44
Issue
1
Pages
127 - 138
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