Linearization of the Disposition Index equation allows evaluation of secretion-sensitivity coupling slopes

The Disposition Index (DI) is widely used in clinical studies of β-cell function. However, direct physiologic interpretation of the DI value and the inverse exponential slope relating insulin secretion and insulin sensitivity terms is difficult. We evaluated a linearization of the relationship that allows separate evaluation of the DI term and the slope. Insulin secretion and sensitivity indices were derived from standardized oral glucose...