Convergent synthesis, free radical scavenging, Lineweaver‐Burk plot exploration, hemolysis and in silico study of novel indole‐phenyltriazole hybrid bearing acetamides as potent urease inhibitors

In the current paper, through a convergent multi‐step approach, a library of novel indole‐phenyltriazole hybrids containing an amide moiety ( 9a‐k) was synthesized. The structural verification of all synthesized molecules was accomplished by CHN and spectral analyses data. These synthesized bi‐heterocyclic derivatives ( 9a‐k ) were evaluated for their anti‐ulcer potential by inhibitory action against Jack bean urease enzyme and subsequently...