Dkn-01 treated patients with recurrent epithelial endometrial (EEC) or ovarian (EOC) cancers which harbor Wnt activating mutations have longer progression-free survival and improved clinical benefit
Abstract
Objective: Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that promotes tumor cell proliferation, angiogenesis, and metastasis and contributes to an immune suppressive tumor microenvironment. Activating mutations of the Wnt/Beta-catenin dependent signaling pathway result in increased tumor production of DKK1. We assessed whether patients whose tumors harbor Wnt-activating mutations have improved clinical outcomes to DKN-01 (DKK1...
Paper Details
Title
Dkn-01 treated patients with recurrent epithelial endometrial (EEC) or ovarian (EOC) cancers which harbor Wnt activating mutations have longer progression-free survival and improved clinical benefit
Published Date
Oct 1, 2020
Journal
Volume
159
Pages
5 - 6
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Notes
History