Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders
Abstract
Substantial genetic liability is shared across psychiatric disorders but less is known about risk variants that are specific to a given disorder. We used multi-trait conditional and joint analysis (mtCOJO) to adjust GWAS summary statistics of one disorder for the effects of genetically correlated traits to identify putative disorder-specific SNP associations. We applied mtCOJO to summary statistics for five psychiatric disorders from the...
Paper Details
Title
Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders
Published Date
May 12, 2020
Journal
Volume
26
Issue
6
Pages
2070 - 2081
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