Kinetics of crystalloid fluid in hyperglycemia; an open‐label exploratory clinical trial

Background Infusion with 0.9% saline is a mainstay in the treatment of severe hyperglycemia, but the kinetics of the saline volume in this setting has not been studied. Methods An intravenous infusion of 1 L of 0.9% saline over 30 minutes was given on 31 occasions to 17 patients with hyperglycemia due to poorly controlled diabetes (mean age 51 years). A two‐volume kinetic model was fitted to serial data on the hemodilution and urinary excretion,...