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Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations

Published on Apr 29, 2020in NMR in Biomedicine3.414
· DOI :10.1002/NBM.4309
Andrew A. Maudsley53
Estimated H-index: 53
(UM: University of Miami),
Ovidiu C. Andronesi26
Estimated H-index: 26
(Harvard University)
+ 7 AuthorsBrian J. Soher34
Estimated H-index: 34
(Duke University)
Abstract
Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains largely confined to the research community and a limited number of clinical sites. The MRSI methods currently implemented on clinical MRI instruments have remained essentially unchanged for two decades, with only incremental improvements in sequence implementation. During this time, a number of technological developments have taken place that have already greatly benefited the quality of MRSI measurements within the research community and which promise to bring advanced MRSI studies to the point where the technique becomes a true imaging modality, while making the traditional review of individual spectra a secondary requirement. Furthermore, the increasing use of biomedical MR spectroscopy studies has indicated clinical areas where advanced MRSI methods can provide valuable information for clinical care. In light of this rapidly changing technological environment and growing understanding of the value of MRSI studies for biomedical studies, this article presents a consensus from a group of experts in the field that reviews the state-of-the-art for clinical proton MRSI studies of the human brain, recommends minimal standards for further development of vendor-provided MRSI implementations, and identifies areas which need further technical development.
  • References (195)
  • Citations (1)
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References195
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#1Martin Wilson (University of Birmingham)H-Index: 20
#2Ovidiu C. Andronesi (Harvard University)H-Index: 26
Last. Franklyn A. Howe (St George's, University of London)H-Index: 54
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Proton MRS (1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good access to MR research support. Widespread adoption has been slow for several reasons, and technical challenges toward obtaining reliable good-quality results have been identified as a contributing facto...
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#1Sho Moriguchi (Keio: Keio University)H-Index: 7
#2Akihiro Takamiya (Keio: Keio University)H-Index: 6
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Alterations in glutamatergic neurotransmission are implicated in the pathophysiology of depression, and the glutamatergic system represents a treatment target for depression. To summarize the nature of glutamatergic alterations in patients with depression, we conducted a meta-analysis of proton magnetic resonance (1H-MRS) spectroscopy studies examining levels of glutamate. We used the search terms: depress* AND (MRS OR “magnetic resonance spectroscopy”). The search was performed with MEDLINE, Em...
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#1Avinash Chandra ('KCL': King's College London)H-Index: 5
#2George Dervenoulas ('KCL': King's College London)H-Index: 3
Last. Marios Politis ('KCL': King's College London)H-Index: 38
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Research utilizing magnetic resonance imaging (MRI) has been crucial to the understanding of the neuropathological mechanisms behind and clinical identification of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). MRI modalities show patterns of brain damage that discriminate AD from other brain illnesses and brain abnormalities that are associated with risk of conversion to AD from MCI and other behavioural outcomes. This review discusses the application of various MRI techniques to...
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