Interleukin-17A, -F, and -AF induce expression of pro-inflammatory genes in end-stage osteoarthritis chondrocytes and synovial fibroblasts

Volume: 28, Pages: S114 - S114
Published: Apr 1, 2020
Abstract
Purpose: Interleukin (IL)-17 is a family of 6 cytokines from which the homodimers IL-17A and IL-17F, and the heterodimer IL-17AF are most well-studied. These IL-17-cytokines have a pivotal function in host defence, but have also been linked to several autoimmune and chronic inflammatory diseases due to their ability to stimulate resident fibroblasts to release mediators that contribute to inflammation, angiogenesis, and matrix destruction. In...
Paper Details
Title
Interleukin-17A, -F, and -AF induce expression of pro-inflammatory genes in end-stage osteoarthritis chondrocytes and synovial fibroblasts
Published Date
Apr 1, 2020
Volume
28
Pages
S114 - S114
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