FOXO1 deficiency impairs proteostasis in aged T cells

Volume: 6, Issue: 17
Published: Apr 24, 2020
Abstract
T cell differentiation involves the dynamic regulation of FOXO1 expression, which rapidly declines after activation and is subsequently restored. Reexpression is impaired in naïve CD4+ T cell responses from older individuals. Here, we show that FOXO1 promotes lysosome function through the induction of the key transcription factor for lysosomal proteins, TFEB. Subdued FOXO1 reexpression in activated CD4+ T cells impairs lysosomal activity,...
Paper Details
Title
FOXO1 deficiency impairs proteostasis in aged T cells
Published Date
Apr 24, 2020
Volume
6
Issue
17
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