Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer.

Volume: 26, Issue: 15, Pages: 4135 - 4142
Published: Apr 24, 2020
Abstract
Purpose: null DNA damage response and repair (DDR) gene alterations are associated with increased tumor-infiltrating lymphocytes, higher genomic instability, and higher tumor mutational burden (TMB) in cancer. Whether DDR alterations are associated with clinical outcomes to programmed death ligand 1 [PD-(L)1] blockade in non–small cell lung cancer (NSCLC) is unknown. null Experimental Design: null Tumors from patients treated with PD-(L)1...
Paper Details
Title
Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer.
Published Date
Apr 24, 2020
Volume
26
Issue
15
Pages
4135 - 4142
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