Original paper
Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets
Volume: 106, Issue: 5, Pages: 679 - 693
Published: May 1, 2020
Abstract
Accurate construction of polygenic scores (PGS) can enable early diagnosis of diseases and facilitate the development of personalized medicine. Accurate PGS construction requires prediction models that are both adaptive to different genetic architectures and scalable to biobank scale datasets with millions of individuals and tens of millions of genetic variants. Here, we develop such a method called Deterministic Bayesian Sparse Linear Mixed...
Paper Details
Title
Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets
Published Date
May 1, 2020
Volume
106
Issue
5
Pages
679 - 693
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