Branch point control at malonyl-CoA node: A computational framework to uncover the design principles of an ideal genetic-metabolic switch

Living organism is an intelligent system coded by hierarchically-organized information to perform precisely-controlled biological functions. Biophysical models are important tools to uncover the design rules underlying complex genetic-metabolic circuit interactions. Based on a previously engineered synthetic malonyl-CoA switch (Xu et al., PNAS, 2014), we have formulated nine differential equations to unravel the design principles underlying an...