NRF2 as a regulator of cell metabolism and inflammation in cancer
Abstract
Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcriptional regulator of genes whose products defend our cells for toxic and oxidative insults. Although NRF2 activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting inflammation, many cancers exhibit elevated NRF2 activity either due to mutations that disrupt the negative control of NRF2 activity or other factors. Importantly, NRF2 activation is...
Paper Details
Title
NRF2 as a regulator of cell metabolism and inflammation in cancer
Published Date
Apr 1, 2020
Journal
Volume
41
Issue
4
Pages
405 - 416
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