Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.
Abstract
Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with...
Paper Details
Title
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.
Published Date
Apr 27, 2020
Journal
Volume
52
Issue
5
Pages
482 - 493
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Notes
History