Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence
Abstract
Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C (CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity...
Paper Details
Title
Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence
Published Date
Jun 1, 2021
Volume
11
Issue
3
Pages
340 - 350
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