Prolactin stimulates the vascularisation of the retina in newborn mice under hyperoxia conditions

The hormone prolactin (PRL) is emerging as an important regulator of ocular blood vessels. PRL is pro‐angiogenic and acquires anti‐angiogenic properties after undergoing proteolytic cleavage to the PRL fragment, vasoinhibin. The vascularisation of the rodent retina develops after birth when it rapidly expands until completion at the end of the first postnatal week. Exposure of newborn mice to high oxygen levels lowers the rate of blood vessel...