Tropisetron improves pancreas function and increases insulin synthesis and secretion in the STZ-induced diabetic rats: involvement of UCP2/ZnT8 pathway

Volume: 72, Issue: 8, Pages: 1082 - 1091
Published: Apr 29, 2020
Abstract
Objectives Diabetes mellitus is one of the most common metabolic diseases. Tropisetron, as a 5-HT3 receptor antagonist, has a considerable role in the inflammation and oxidative stress lowering. This study aimed to investigate the effect of this 5-HT3 receptor antagonist on insulin secretion in male diabetic rats and the possible mechanisms. Methods Animals were divided into five equal groups; the control, tropisetron, diabetes,...
Paper Details
Title
Tropisetron improves pancreas function and increases insulin synthesis and secretion in the STZ-induced diabetic rats: involvement of UCP2/ZnT8 pathway
Published Date
Apr 29, 2020
Volume
72
Issue
8
Pages
1082 - 1091
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