BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy
Abstract
Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-regulation of the balance between proliferation and apoptosis contributes to tumor initiation. Particularly in the colon where apoptosis is a crucial process in intestinal turnover, inhibition of apoptosis facilitates transformation and tumor progression. The BCL-2 family of proteins are key regulators of apoptosis and have been implicated in colorectal...
Paper Details
Title
BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy
Published Date
Apr 25, 2020
Journal
Volume
25
Issue
5-6
Pages
305 - 320
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Notes
History