Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome
Abstract
Genome-wide association studies on bipolar disorders (BD) have revealed an additive polygenic contribution of common single-nucleotide polymorphisms (SNPs). However, these SNPs explain only 25% of the overall genetic variance and suggest a role of rare variants in BD vulnerability. Here, we combined high-throughput genotyping data and whole-exome sequencing in cohorts of individuals with BD as well as in multiplex families with a high density of...
Paper Details
Title
Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome
Published Date
Apr 28, 2020
Journal
Volume
10
Issue
1
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