The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy
Abstract
Lineage-specific genetic programs rely on cell-restricted super-enhancers, which are platforms for high-density transcription factor occupation. It is not known whether super-enhancers synergize specifically with their native promoters or provide autonomous and independent regulatory platforms. Here, we investigated the ability of the mammary Wap super-enhancer to activate the promoter of the juxtaposed and ubiquitously expressed Tbrg4 gene in...
Paper Details
Title
The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy
Published Date
Apr 1, 2020
Volume
52
Issue
4
Pages
682 - 690
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