Robotically handled whole-tissue culture system for the screening of oral drug formulations

Volume: 4, Issue: 5, Pages: 544 - 559
Published: Apr 27, 2020
Abstract
Monolayers of cancer-derived cell lines are widely used in the modelling of the gastrointestinal (GI) absorption of drugs and in oral drug development. However, they do not generally predict drug absorption in vivo. Here, we report a robotically handled system that uses large porcine GI tissue explants that are functionally maintained for an extended period in culture for the high-throughput interrogation (several thousand samples per day) of...
Paper Details
Title
Robotically handled whole-tissue culture system for the screening of oral drug formulations
Published Date
Apr 27, 2020
Volume
4
Issue
5
Pages
544 - 559
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