BnpC: Bayesian non-parametric clustering of single-cell mutation profiles
Abstract
Motivation The high resolution of single-cell DNA sequencing (scDNA-seq) offers great potential to resolve intratumor heterogeneity (ITH) by distinguishing clonal populations based on their mutation profiles. However, the increasing size of scDNA-seq datasets and technical limitations, such as high error rates and a large proportion of missing values, complicate this task and limit the applicability of existing methods. Results Here, we...
Paper Details
Title
BnpC: Bayesian non-parametric clustering of single-cell mutation profiles
Published Date
Jun 27, 2020
Journal
Volume
36
Issue
19
Pages
4854 - 4859
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