Depression moderates analgesic effectiveness among individuals with radiographic knee osteoarthritis

Purpose: Depression is a common comorbidity in persons with knee osteoarthritis (OA) and affects approximately 20% of this population. The co-occurrence of depression with knee OA is associated with more severe and persistent pain and may negatively affect clinical outcomes of analgesic treatments. Therefore, the study objective was to determine whether depression is an effect modifier of analgesic effectiveness with respect to its treatment...