Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease
Abstract
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differentiation, cell migration, and axon development. We highlight recent evidence indicating that Huwe1 regulates inhibitory neurotransmission. In covering these...
Paper Details
Title
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease
Published Date
Apr 26, 2020
Journal
Volume
15
Issue
1
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