Intra-articular corticosteroids for knee and hip OA: a systematic review of serious adverse joint outcomes

Purpose: Intra-articular corticosteroids (IACS) are proven to provide short-term pain relief and functional improvement in individuals with knee and hip osteoarthritis (OA). However, the potential for serious adverse joint outcomes resulting from long-term use of IACS has been cause for concern. We conducted a systematic review of all RCT data comparing IACS to intra-articular saline to explore the incidence of accelerated OA progression,...