Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

Volume: 11, Issue: 1
Published: Apr 28, 2020
Abstract
Promoter-anchored chromatin interactions (PAIs) play a pivotal role in transcriptional regulation. Current high-throughput technologies for detecting PAIs, such as promoter capture Hi-C, are not scalable to large cohorts. Here, we present an analytical approach that uses summary-level data from cohort-based DNA methylation (DNAm) quantitative trait locus (mQTL) studies to predict PAIs. Using mQTL data from human peripheral blood ([Formula: see...
Paper Details
Title
Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
Published Date
Apr 28, 2020
Volume
11
Issue
1
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