Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy
Abstract
Radiation therapy is capable of directing adaptive immune responses against tumors by stimulating the release of endogenous adjuvants and tumor-associated Ags. Within the tumor, conventional type 1 dendritic cells (cDC1s) are uniquely positioned to respond to these signals, uptake exogenous tumor Ags, and migrate to the tumor draining lymph node to initiate cross-priming of tumor-reactive cytotoxic CD8+ T cells. In this study, we report that...
Paper Details
Title
Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy
Published Date
Jun 15, 2020
Journal
Volume
204
Issue
12
Pages
3416 - 3424
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