Skeletal Muscle Reflex‐Induced Dysregulation of Sympathetic Nerve Activity in Type 1 Diabetic Rats

The pressor response to physical exercise is exaggerated in the early stages of type 1 diabetes mellitus (T1DM). This augmented blood pressure (BP) response has been further shown to be mediated by an overactive skeletal muscle exercise pressor reflex (EPR). However, whether alterations in sympathetic responsiveness contribute to this EPR overactivity is unknown. The purpose of this study was to test the hypothesis that the potentiated BP...