SASP from lung senescent fibroblasts induces immunesenescence and fibrosis

Rationale Lung aging is characterized by a progressive functional impairment. One of the main features of aging is the accumulation of senescent cells, a phenotype that has been described in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF). Senescent cells produce the senescence‐associated secretory phenotype (SASP), which is highly variable. Understanding SASP components would provide a new insight into the different...