Propofol Postconditioning Ameliorates Hypoxia/Reoxygenation induced H9c2 Cells Apoptosis and Autophagy via upregulating Forkhead Transcription Factors under Hyperglycemia

Administration of propofol, an intravenous anesthetic with antioxidant property, immediately at the onset of post‐ischemic reperfusion (propofol postconditioning, P‐PostC) has been shown to confer cardioprotection against ischemia‐reperfusion injury , while the underlying mechanism remains incompletely understood. Also, whether or not P‐PostC can confer cardioprotection in diabetes or under hyperglycemic condition has yet to be explored. The...