Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells
Abstract
Background The use of immunotherapy strategies for the treatment of advanced cancer is rapidly increasing. Most immunotherapies rely on induction of CD8+ tumor-specific cytotoxic T cells that are capable of directly killing cancer cells. Tumors, however, utilize a variety of mechanisms that can suppress anti-tumor immunity. CD4+ regulatory T cells can directly inhibit cytotoxic T cell activity and these cells can be recruited, or induced, by...
Paper Details
Title
Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells
Published Date
Apr 16, 2020
Journal
Volume
21
Issue
1
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