Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice
Abstract
Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflammation and excessive matrix remodelling are considered important in AAA pathogenesis. Kinins are bioactive peptides important in regulating inflammation. Stimulation of the kinin B2 receptor has been previously reported to promote AAA development and rupture in a mouse model. The endogenous B2 receptor agonist, bradykinin, is generated from the...
Paper Details
Title
Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice
Published Date
May 1, 2020
Journal
Volume
134
Issue
9
Pages
1049 - 1061
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