Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction
Abstract
Studies of genetic blood disorders have advanced our understanding of the intrinsic regulation of hematopoiesis. However, such genetic studies have only yielded limited insights into how interactions between hematopoietic cells and their microenvironment are regulated. Here, we describe two affected siblings with infantile myelofibrosis and myeloproliferation that share a common de novo mutation in the Rho GTPase CDC42 (Chr1:22417990:C>T,...
Paper Details
Title
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction
Published Date
Apr 17, 2020
Volume
40
Issue
4
Pages
554 - 566
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