Stereoselective uptake and metabolism of prothioconazole caused oxidative stress in zebrafish (Danio rerio)

Prothioconazole (PTA) is a novel, broad-spectrum, chiral triazole fungicide that is mainly used to prevent and control the disease of cereal crops. However, the adverse effects of PTA and its major metabolite on nontarget organisms have aroused wide concern. In the present work, the acute toxic of the metabolite prothioconazole-desthio (PTA-desthio), with an LC50 of 1.31 mg L-1, was 3.5-fold more toxic than the parent compound, indicating that...