Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia
Abstract
Early-onset schizophrenia is a severe and rare form of schizophrenia that is clinically and neurobiologically continuous with the adult form of schizophrenia. Neuregulin1 (NRG1)-mediated signaling is crucial for early neurodevelopment, which exerts its function by limited β-secretase 1 (BACE1) proteolysis processing. However, circulating neuregulin1-β1 (NRG1-β1), an isoform of NRG1, and its cleavage enzyme BACE1 have not been studied in...
Paper Details
Title
Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia
Published Date
Jul 1, 2020
Journal
Volume
100
Pages
152176 - 152176
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