Regulation of interleukin 6 by a polymorphic CpG within the frontal cortex in Alzheimer’s disease
Abstract
The cytokine interleukin 6 (IL-6) has been linked to the pathogenesis of Alzheimer’s disease (AD). This is the first study to investigate the genetic and epigenetic interactions in the control of IL-6 in human brain and its relation to AD neuropathology in prefrontal cortex tissues from AD and controls genotyped for the SNP −174 C/G rs1800795, a polymorphic CpG in which the G allele creates a CpG site. Within CC homozygotes there were...
Paper Details
Title
Regulation of interleukin 6 by a polymorphic CpG within the frontal cortex in Alzheimer’s disease
Published Date
Aug 1, 2020
Journal
Volume
92
Pages
75 - 81
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