Beyond structure: emerging approaches to study GPCR dynamics
Abstract
• GPCRs are highly dynamic proteins that sample multiple conformational states. • Dynamic behavior of GPCRs can be described using the concept of energy landscapes. • Understanding signaling mechanisms requires both structure and dynamics. • New approaches uncover GPCR dynamics in population and at a single molecule level. G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins that are involved in regulation...
Paper Details
Title
Beyond structure: emerging approaches to study GPCR dynamics
Published Date
Aug 1, 2020
Volume
63
Pages
18 - 25
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