With great power comes great… reliability

This article refers to ‘Mega-trials in heart failure: effects of dilution in examination of new therapies’ by B.A. Davison et al., published in this issue on pages 1698–1707. The sheer number of medical ailments that afflict humans far surpasses our ability to effectively alter the natural course of most diseases. Yet, modern evidence-based medicine has catapulted remarkable gains for both the prevention and chronic management of cardiovascular...