Distinct neurotoxic effects of select local anesthetics on facial nerve injury and recovery

Background:Local anesthetic toxicity has been well-documented to cause neuronal injury, death, and dysfunction, particularly in a susceptible nerve. Objective:To determine whether select local anesthetics affect neuron survival and/or functional recovery of an injured nerve. Methods:This report des cribes 6 separate experiments that test immediate or delayed application of local anesthetics in 3 nerve injury models. Adult C57/black6 male mice...