Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling
Abstract
Chemically modified antigen-binding proteins are widely applied for their targeting abilities in the fields of biotechnology, medicine, and diagnostics. However, the production of site-selectively modified proteins remains a challenge. Here, we have designed a chemical probe for the introduction of a reactive aldehyde on nanobodies by metal-complex-guided conjugation. The probe design allows for purification of the conjugates, and the aldehyde...
Paper Details
Title
Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling
Published Date
Apr 22, 2020
Journal
Volume
31
Issue
5
Pages
1295 - 1300
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