Investigation of Cell Envelope‐Associated Proteins in Rumen Methanogens as Targets for Understanding Host‐Microbe Interactions

The rumen microbiota is complex and almost totally composed of anaerobic organisms, including methanogenic archaea (methanogens). The latter occupy a unique niche in the rumen, using hydrogen, formate and methyl compounds to produce methane. Many of the proteins predicted from analysis of genome sequences of rumen‐dwelling methanogens, in particular cell envelope‐associated proteins, have no known biological function. To elucidate the role of...