Redistribution of Monocarboxylate 1 and 4 in Hippocampus and Spatial Memory Impairment Induced by Long-term Ketamine Administration

The monocarboxylate transporters MCT1, MCT2, and MCT4 are essential components of the astrocyte-neuron lactate shuttle, which is a fundamental element of brain energetics. Decreased expression of monocarboxylate transporters can induce cognitive dysfunction of the brain. In present study, we established a mouse model of long-term ketamine administration by subjecting mice to a 6-month course of a daily intraperitoneal injection of ketamine....