Frailty transitions, inflammation, and mortality among persons aging with HIV infection and injection drug use

Frailty is a critical aging-related syndrome marked by diminished physiologic reserve and heightened vulnerability to stress, predictive of major adverse clinical outcomes in HIV-infected and uninfected adults. Frailty is a dynamic state, yet little data exist on predictors and consequences of frailty transitions.Frailty was assessed semiannually among HIV-infected and uninfected persons with prior injection drug use using the five Fried...