Ospemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities
Abstract
Azole antifungals are vital therapeutic options for treating invasive mycotic infections. However, the emergence of azole-resistant isolates combined with limited therapeutic options presents a growing challenge in medical mycology. To address this issue, we utilized microdilution checkerboard assays to evaluate nine stilbene compounds for their ability to interact synergistically with azole drugs, particularly against azole-resistant fungal...
Paper Details
Title
Ospemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities
Published Date
Apr 8, 2020
Journal
Volume
10
Issue
1
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